Photos published by the local media show a bus shattered into pieces with a disability sign next to a truck.
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“Unfortunately, 21 bus passengers died,” and four people were injured, reported the company “Via Araucaria,” which manages several highways in the state of Paraná, to which the municipality of Imbituva belongs.
The accident occurred on a highway connecting the southern part of the country with São Paulo – the richest state in Brazil.
According to local media, the passenger vehicle was transporting patients to various medical centers.
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Officials did not provide any information about the truck driver and other people who might have been in it.
Fatal traffic accidents are common in Brazil.
On Sunday, eight people died in the state of Rio de Janeiro when the bus carrying them overturned.
In February, a bus returning from a religious festival in northeastern Brazil went off the road and overturned. At least 16 people died in that accident.
